Temporary Scientist
Temporary Scientist 1/ Scientist 2
Biochemical and Cellular Pharmacology, Genentech, Inc.
We have an opening for a talented temporary Scientist 1/Scientist 2 to join our Biochemical and Cellular Pharmacology Department. The successful candidate will be responsible for supporting chromatographic, electrophoretic and/or mass spectrometric characterization of antibody and protein therapeutics. More specifically, the individual will focus on developing, validating, and executing various assays to evaluate antibody therapeutics from both in vitro and in vivo studies to support lead-finding/optimization efforts in the context of multidisciplinary project teams. The individual will be expected to assist in the implementation of robust and high throughput sample preparation as well as data analysis workflows for mass spectrometric assays. The candidate will have the opportunity to conduct detailed data analyses and will present these data to project teams. In addition, the candidate will have an opportunity to develop novel cutting edge technologies for pharmacological assays. The candidate will also be expected to coordinate with CRO and handle shipments. In addition, the candidate will function as part of a multi-disciplinary project team that will coordinate with protein science, chemistry, in vitro and in vivo groups to advance lead molecules of the projects. Pay and position will be determined based on qualifications and experience level.
Requirements:
The qualified individual will possess a B.S. or M.S. in analytical biochemistry with 0-5 years of lab experience in academia, biotechnology and/or pharmaceutical industry. Practical experience in the design, development, validation, and execution of electrophoresis, ELISA, liquid chromatography, mass spectrometric characterization of intact proteins and peptides, while not required, is a plus. Experience with affinity capture, while not required, is a plus. Experience with commonly used mass spectrometers and both qualitative and quantitative data analysis methods and software is also not required, but a plus. Familiarity with automated or semi-automated instrumentation, while not required, would be advantageous, as would familiarity with the multi-disciplinary activities of antibody lead profiling. The position requires good communication skills and the ability to work well as part of a team. It also requires excellent time management and organizational skills.